Negative bionomial model (test) vs T test in EBseq or DEseq2
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hkang • 0
@hkang-12345
Last seen 4.5 years ago

Hi

I'm wondering if T test can be used for differentiation expression analysis with RNAseq data, and which one is better for DE analysis, T test or negative binomial model (test /  distribution), and why?

Thanks,

HyunJun

negative binomial model • 591 views
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Just read some papers, e.g.

Anders, S. and Huber, W., 2012. Differential expression of RNA-Seq data at the gene level–the DESeq package. Heidelberg, Germany: European Molecular Biology Laboratory (EMBL).

Law, C.W., Chen, Y., Shi, W. and Smyth, G.K., 2014. Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome biology, 15(2), p.R29.

 

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