Negative bionomial model (test) vs T test in EBseq or DEseq2
0
0
Entering edit mode
hkang • 0
@hkang-12345
Last seen 7.1 years ago

Hi

I'm wondering if T test can be used for differentiation expression analysis with RNAseq data, and which one is better for DE analysis, T test or negative binomial model (test /  distribution), and why?

Thanks,

HyunJun

negative binomial model • 1.1k views
ADD COMMENT
1
Entering edit mode

Just read some papers, e.g.

Anders, S. and Huber, W., 2012. Differential expression of RNA-Seq data at the gene level–the DESeq package. Heidelberg, Germany: European Molecular Biology Laboratory (EMBL).

Law, C.W., Chen, Y., Shi, W. and Smyth, G.K., 2014. Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome biology, 15(2), p.R29.

 

ADD REPLY

Login before adding your answer.

Traffic: 731 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6