I have some miRNA raw counts of the patients samples before and after drug treatment. The problem is the blood samples were taken on different dates. Here are the fine details
Patient1: Before Treatment (BT), Day 14, 18,30
Patient 2: BT, Day 9,17
Patient 3: BT, Day 6,8
Patient 4: BT, Day 3,6
Patient 5: BT, Day 8,24
i tried using from the examples of DESeq2 for paired samples but unsuccessful probably because of different time points. Any help would highly appreciated.