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Question: P-value distribution acceptable for qvalue
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gravatar for kerrypop
17 months ago by
kerrypop20
kerrypop20 wrote:

In the qvalue vignette, it states data with a U-shaped p-value histogram is a red flag. If distribution resembles either of the following, is it appropriate to use this package? Thank you.

ADD COMMENTlink modified 17 months ago by Laurent Gatto1.0k • written 17 months ago by kerrypop20
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gravatar for Laurent Gatto
17 months ago by
Laurent Gatto1.0k
United Kingdom
Laurent Gatto1.0k wrote:

The distribution certainly look weird, and it would be important to understand why they show such a conservative trend. Could it be that their have already been adjusted? This post is relevant.

Anyway, applying qvalue, or any adjustment, is not going to be of any help without first troubleshooting your p-value distribution.

ADD COMMENTlink written 17 months ago by Laurent Gatto1.0k
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