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Question: P-value distribution acceptable for qvalue
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gravatar for kerrypop
5 months ago by
kerrypop0
kerrypop0 wrote:

In the qvalue vignette, it states data with a U-shaped p-value histogram is a red flag. If distribution resembles either of the following, is it appropriate to use this package? Thank you.

ADD COMMENTlink modified 5 months ago by Laurent Gatto840 • written 5 months ago by kerrypop0
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gravatar for Laurent Gatto
5 months ago by
Laurent Gatto840
United Kingdom
Laurent Gatto840 wrote:

The distribution certainly look weird, and it would be important to understand why they show such a conservative trend. Could it be that their have already been adjusted? This post is relevant.

Anyway, applying qvalue, or any adjustment, is not going to be of any help without first troubleshooting your p-value distribution.

ADD COMMENTlink written 5 months ago by Laurent Gatto840
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