**0**wrote:

Hello,

I have a question regarding the qvalues. I have a dataset of 240 metabolites and I did univariate tests, generating 240 p-values. I then calculated the qvalues from these pvalues, and got few qvalues that are actually lower than the pvalues (e.g. pvalue = 0.07; qvalue = 0.03). I understand that this is technically possible, but I'm not sure about the interpretation. In other forums I have read that this could be because the proportion of truly null p-values is not very accurately calculated when the number of tests is not large enough (in this case 240). Any advice??

Thanks very much,

Andrea