I noticed that MAST sometimes has NA for the continuous coefficient. When this happens, it also has NA for the estimated fold change. I couldn't find much in the documentation about this, but I was wondering if someone can explain it?
This is a problem for me because I'm trying to select the most differentially expressed genes using the fold change. But when I do this, I noticed that some genes are being left out, even though they have very large discrete components. The only solution is to select genes using the discrete component, ignoring the continuous component altogether, but at this point, I should just use logistic regression.
If someone can help out at all, I would really appreciate it. Thanks!