I'm seeing download errors with Bioconductor 3.12 for some packages currently, primarily some large data packages.
Here's an example error with reactome.db:
Bioconductor version 3.12 (BiocManager 1.30.10), R 4.0.3 (2020-10-10) Installing package(s) 'reactome.db' installing the source package ‘reactome.db’ trying URL 'https://bioconductor.org/packages/3.12/data/annotation/src/contrib/reactome.db_1.74.0.tar.gz' Content type 'application/x-gzip' length 430092992 bytes (410.2 MB) ================ downloaded 137.5 MB Error in download.file(url, destfile, method, mode = "wb", ...) : (converted from warning) downloaded length 144140511 != reported length 430092992 Calls: install ... tryCatchList -> tryCatchOne -> doTryCatch -> download.file
I'm also seeing this with some of the BSgenome packages.
R version 4.0.3 (2020-10-10) Platform: x86_64-apple-darwin17.0 (64-bit) Running under: macOS Catalina 10.15.7 Matrix products: default BLAS: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.dylib LAPACK: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib locale:  en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 attached base packages:  stats graphics grDevices utils datasets methods base other attached packages:  bb8_0.2.32 loaded via a namespace (and not attached):  compiler_4.0.3 BiocManager_1.30.10 magrittr_1.5  tools_4.0.3 crayon_1.3.4 remotes_2.2.0  rlang_0.4.8