Hello everyone . I have a count matrix of sequencing data showing how many fragments there is in each region here is a few rows of my data

```
head(data[,1:6])
[,1] [,2] [,3] [,4] [,5] [,6]
1 3 6 0 0 3 1
2 4 4 0 0 0 0
3 4 4 1 0 2 2
4 0 2 0 0 0 0
5 0 1 0 0 0 0
6 0 5 2 0 0 0
```

I am trying to **GC content normalize** my data
first I did a quantile normalization with `normalize.quantiles`

function and named output `data.norm`

. then I calculated GC content for each region .Finally using `cqn`

i tried to do GC content normalization

```
cqn( data.norm, x=gc ,lengths = rep(500, 590650))
```

but I get the following error

```
Error in qr.default(t(const)) :
NA/NaN/Inf in foreign function call (arg 1)
```

I'm not familiar with cqn package so I don't exactly know what is the problem here