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10
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14
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13k
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how DESeq calculates p-value ?
deseq
differential gene expression
statistics
p-value
updated 3.1 years ago by
Kai_Qi
▴ 20 • written 8.2 years ago by
Giard
▴ 30
8
votes
8
replies
6.7k
views
Voom transformation from counts and normalization to negative values
rnaseq
voom
limma
tcga
statistics
updated 5.6 years ago by
Ryan C. Thompson
★ 7.9k • written 5.6 years ago by
Beginner
▴ 60
25
votes
7
replies
11k
views
Effect of lfcThreshold on p-value in DESeq2
deseq2
rnaseq
statistics
updated 6 months ago by
camillab.
▴ 10 • written 6.5 years ago by
Russ Fraser
▴ 30
0
votes
6
replies
1.3k
views
regression analysis for epic array methylation data using limma
limma
Epigenetics
STATISTICS
R
23 months ago
Jitendra
▴ 10
1
vote
6
replies
2.7k
views
DESeq2 unbalanced sample size
deseq2
bioconductor
bioinformatics
statistics
updated 14 months ago by
Michael Love
41k • written 5.3 years ago by
casikecola
• 0
0
votes
5
replies
1.1k
views
Comparing sets of differentially expressed genes
deseq2
rnaseq
statistics
8.5 years ago
sunkid
• 0
3
votes
5
replies
1.4k
views
P adjusted values in Deseq2
DESeq2
Statistics
written 3.3 years ago by
Jesus
• 0
0
votes
4
replies
2.8k
views
XCMS for targeted metabolomic/lipidomics/proteomics
xcms
metabolomics
lipidomics
statistics
8.3 years ago
Titan
• 0
19
votes
4
replies
8.1k
views
Confidence intervals on edgeR logFC
edgeR
statistics
confidence interval
updated 8.0 years ago by
nwvidal
• 0 • written 9.6 years ago by
ri.lars
▴ 40
1
vote
4
replies
1.2k
views
Do the gene set statistics of the ROAST paper correspond to those implemented in the .roastEffects R function?
limma
roast
statistics
source code
gene set testing
5.7 years ago
Andrea Carenzo
• 0
0
votes
4
replies
5.6k
views
10 multiple comparisons in DESeq2
deseq2
rnaseq
statistics
updated 7.9 years ago by
Michael Love
41k • written 7.9 years ago by
kissmatee
• 0
2
votes
4
replies
1.2k
views
Removing batch effect on edgeR when interactons are looked at
rnaseq
edger
statistics
model matrix
updated 6.6 years ago by
Steve Lianoglou
★ 13k • written 6.6 years ago by
David R
▴ 90
0
votes
3
replies
921
views
batch effect in EPIC array data
statistics
Epigenetics
R
updated 14 months ago by
Lluís Revilla Sancho
▴ 730 • written 14 months ago by
Jitendra
▴ 10
8
votes
3
replies
3.2k
views
Differing topTable() results with Limma with and without specifying coefficient
limma
microarray
statistics
updated 8.0 years ago by
Gordon Smyth
50k • written 8.0 years ago by
krr
• 0
2
votes
3
replies
1.5k
views
RNAseq outlier is a critical sample
rnaseq
outlier
statistics
batch effect
updated 7.9 years ago by
Gordon Smyth
50k • written 7.9 years ago by
grastalt27
• 0
3
votes
3
replies
1.4k
views
Using alternative LFC shrinkage methods for computing p-values in DESeq2
deseq2
apeglm
statistics
updated 4.9 years ago by
Michael Love
41k • written 4.9 years ago by
zefrieira
• 0
0
votes
3
replies
1.5k
views
Reading large file (15GB) in R
R
Rstudio
Bioconducter
statistics
updated 2.2 years ago by
Sean Davis
21k • written 2.3 years ago by
Jitendra
▴ 10
0
votes
2
replies
1.3k
views
Compute test-score statistical significance using control-scores from shuffled population
statistics
hypotheses
R
8.1 years ago
Bade
▴ 310
1
vote
2
replies
2.0k
views
how to perform pre ranked GSEA in R?
r
microarray
statistics
GSEA
updated 7.1 years ago by
predeus
• 0 • written 9.1 years ago by
Nemo
▴ 80
1
vote
2
replies
954
views
What to do with microarray probes that catch multiple genes?
affymetrix microarrays
microarray
probe
statistics
updated 5.6 years ago by
James W. MacDonald
65k • written 5.7 years ago by
ravelarvargas
• 0
0
votes
2
replies
683
views
Results analysis of differential gene expression using DESeq2 package
RnaSeqSampleSize
statistics
DESeq2
updated 16 months ago by
swbarnes2
★ 1.3k • written 16 months ago by
N
• 0
0
votes
2
replies
1000
views
News:
Ascona Workshop “Biological systems: from first principles to data-driven modelling and back” 27. 3. - 1. 4. 2022
theory
modeling
statistics
ascona
Workshop
2.5 years ago • updated 15 months ago
Wolfgang Huber
★ 13k
2
votes
2
replies
7.7k
views
edgeR: How is FDR calculated for logFC? (False Discovery Rate)
edgeR
bioconductor
fdr
statistics
differential gene expression
7.4 years ago
jol.espinoz
▴ 40
1
vote
2
replies
930
views
Newbie to all of this
bioconductor
statistics
5.5 years ago
sportwoo
• 0
0
votes
2
replies
1.1k
views
comparing two GOstats result lists
gostats
statistics
updated 5.9 years ago by
James W. MacDonald
65k • written 5.9 years ago by
sven.schenk
▴ 20
1
vote
2
replies
2.7k
views
the statistical test that DESeq2 use
deseq2
statistics
updated 7.2 years ago by
Ryan C. Thompson
★ 7.9k • written 7.2 years ago by
elhamdallalbashi
• 0
1
vote
2
replies
1.1k
views
Re-calculation of Padj (P adjusted value)
statistics
Benjamini–Hochberg procedure
deseq2
updated 3.5 years ago by
Michael Love
41k • written 3.5 years ago by
Matan G.
▴ 60
2
votes
2
replies
2.8k
views
How adjusted p-values are calculated in limma
limma
r
transcriptomics
FDR
statistics
updated 4.6 years ago by
Gordon Smyth
50k • written 4.6 years ago by
Wuschel
▴ 10
1
vote
1
reply
341
views
Further analysis after limma regression output
statistics
Epigenetics
limma
updated 7 months ago by
James W. MacDonald
65k • written 7 months ago by
Jitendra
▴ 10
0
votes
1
reply
769
views
How to handle batch effect and interaction with experimental variables
deseq2
statistics
differential expression
4.4 years ago
A
• 0
1
vote
1
reply
1.3k
views
FPKM t-test vs DEseq2
DESeq2
statistics
rna-seq
updated 12 months ago by
ATpoint
★ 4.0k • written 12 months ago by
SH
• 0
0
votes
1
reply
755
views
Exclude interaction terms from the design
deseq2
statistics
modelling
updated 4.5 years ago by
Michael Love
41k • written 4.5 years ago by
polyptwo
• 0
0
votes
1
reply
317
views
DEseq2 : Complex design with a mixture of male and female mice
statistics
DESeq2
updated 4 months ago by
Michael Love
41k • written 5 months ago by
lionel.spinelli
• 0
0
votes
1
reply
964
views
Efficient resampling in GENESIS or another Bioconductor GWAS package to obtain empirical p-values?
GENESIS
GWAS
resampling
resample
statistics
5.2 years ago
naglemi
▴ 10
2
votes
1
reply
980
views
limma for gene expression analysis with big and unbalanced sample size
limma
microarray
statistics
updated 7.9 years ago by
Aaron Lun
★ 28k • written 7.9 years ago by
tati6406
• 0
3
votes
0
replies
2.2k
views
Job:
Postdoctoral Scientist, Statistical Bioinformatics and Proteomics, WEHI Australia
job
proteomics
Job
statistics
4.5 years ago • updated 4.3 years ago
Gordon Smyth
50k
1
vote
0
replies
876
views
Job:
Post-Doctoral Research Fellow, Cancer Genomics
genomics
seattle
bioinformatics
data science
statistics
Job
3.9 years ago
Fred Hutch (Recruiting)
▴ 40
0
votes
0
replies
757
views
Job:
Two Bioinformatics Fellowship Positions at US EPA
bioinformatics
toxicology
Job
sequenicng
statistics
3.7 years ago • updated 3.5 years ago
whduke
• 0
2
votes
0
replies
845
views
Job:
Multiple open positions in biomedical statistics at Eurac Research, Italy
epidemiology
statistics
bioinformatics
Job
3.6 years ago
Johannes Rainer
★ 2.0k
0
votes
0
replies
906
views
Job:
Biostatistics/Bioinformatics Research Scientist at UNC Charlotte
R
statistics
pathview
singlecellRNA-Seq
3.4 years ago • updated 3.1 years ago
Luo Weijun
★ 1.6k
0
votes
0
replies
1.1k
views
Job:
Proteomics Bioinformatician
JobPosting
Proteomics
Statistics
Job
3.3 years ago
Laura
• 0
0
votes
0
replies
883
views
Job:
Scientist/Senior Scientist, Statistical Geneticist
Sequencing
Genetics
GeneticsPed
statistics
3.3 years ago
António Miguel de Jesus Domingues
▴ 490
0
votes
0
replies
933
views
Job:
Bioinformatician at MiroBio, Oxford, UK
Transcriptomics
Bioconductor
Statistics
Job
Biocon
3.1 years ago
m.jackson
• 0
0
votes
0
replies
214
views
multipollutant models
statistics
Regression
r
limma
4 months ago
Jitendra
▴ 10
0
votes
0
replies
906
views
Job:
Biostatistics/Bioinformatics Research Scientist at UNC Charlotte
singlecellRNA-Seq
pathview
statistics
R
3.1 years ago • updated 3.0 years ago
Luo Weijun
★ 1.6k
0
votes
0
replies
2.0k
views
Job:
Full position as Statistician at ETH Zurich in Personalized Medicine Consultancy/Data Analysis
statistics
consultancy
personalized medicine
Job
9.5 years ago
Daniel Stekhoven
▴ 10
0
votes
0
replies
644
views
Job:
PhD position in Bioinformatics in Jena
Statistics
ComputationalBiology
Aging
MachineLearning
15 months ago
alena.vanboemmel
• 0
0
votes
0
replies
167
views
Job:
Statistics Lectureships at St Andrews
JobPosting
computational
statistics
8 weeks ago
Andy Lynch
▴ 120
1
vote
0
replies
621
views
Statistical test for genomic annotation by ChIPseeker
statistics
PeakAnnotation
ChIPseeker
GuangchuangYu
20 months ago
arisarkar88
▴ 40
1
vote
0
replies
742
views
Job:
Research Fellow in Prostate Cancer Proteomics (Bioinformatics/Stats/Data Analysis) - University of St Andrews
Multiomics
Proteomics
Cancer
Statistics
Bioinformatics
21 months ago
Andy Lynch
▴ 120
50 results • Page
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Replies
Comment: Trying to use enrichGO
by
Guido Hooiveld
★ 3.9k
Please provide more information! In your first post you seem to report another error than in your 2nd post: `No gene can be mapped...` vers…
Comment: DESeq2 a lot of genes showing up as differentially expressed that only have 1 sa
by
Michael Love
41k
I don't really have any additional suggestion here.
Comment: DESeq2 a lot of genes showing up as differentially expressed that only have 1 sa
by
Seyram M.
• 0
Dear Michael, I tried all three ways (the orIginal, increasing the number of required samples,and subsetting (the countdata and metadata be…
Comment: DESeq2 - dispersion estimation when there is none
by
Michael Love
41k
The red line does assume that shape but the fact the black points show that pattern is discussed in the 2014 paper. > Some caution is warr…
Comment: Error for AnnotationForge makeOrgPackageFromNCBI function
by
James W. MacDonald
65k
I don't really follow what you are saying. All you have to do is delete the NCBI.sqlite db and *re-run the script exactly as you did above.…
Votes
DESeq2: How to find out how well the model fits the data?
Comment: DESeq2 - dispersion estimation when there is none
Comment: DESeq2 a lot of genes showing up as differentially expressed that only have 1 sa
Answer: OrgDb for maize
Answer: DESeq2 - dispersion estimation when there is none
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