User: smurray

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smurray10
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10
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New User
Location:
Seattle
Last seen:
1 month ago
Joined:
1 year, 8 months ago
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s************@gmail.com

Posts by smurray

<prev • 6 results • page 1 of 1 • next >
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Comment: C: Modeling with 'discontinuous' continuous variables, or continuous variables with
... Hi Aaron- Whoops! Let me re-ask my question in a way that doesn’t create a bigger problem than what I’m intending to ask about! (I’’ll leave my original question too, in case it helps anyone with that problem.) Let’s say I have 15 samples from one population and have a continuous variable measure ...
written 4 weeks ago by smurray10
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Modeling with 'discontinuous' continuous variables, or continuous variables with gaps
... Hello, I'm curious about the best way to work with a "spotty" continuous variable, ie a variable that is technically continuous, but there are some gaps in the values such that you might worry a model might not fit too well. For example, say I have fifteen samples in three groups, with a continu ...
limma continuous variable linear modeling written 4 weeks ago by smurray10 • updated 4 weeks ago by Aaron Lun23k
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Comment: C: Paired samples, two time points, two groups and adjust for a continuous variable
... Hello, Just hoping to ask a clarification question- your fourth model matrix above checks whether VO2max and expression change in the same direction- does it also check for genes whose expression changes in the opposite direction? I.e., if expression of a gene decreases between the two time po ...
written 8 weeks ago by smurray10
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Comment: C: Testing for DE genes between samples of isolated cells, accounting for expressio
... Great- thank you for helping me keep it simple! ...
written 20 months ago by smurray10
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Comment: C: Testing for DE genes between samples of isolated cells, accounting for expressio
... Thanks Aaron!  I was hoping that orange and white cat would pop up underneath my post! First, RE: your last warnings, I absolutely agree and am planning to be very cautious with interpretations of results from this technique, and will keep in mind that this strategy may not pick up differences betw ...
written 20 months ago by smurray10
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Testing for DE genes between samples of isolated cells, accounting for expression in whole tissue
... Hi all, I'm hoping to get your advice on how to test for DE genes in samples of cells isolated from a tissue, accounting for the "background" expression in the whole tissue that each sample was isolated from.  Essentially, I'd like help designing a model matrix. The particular laboratory method we ...
rnaseq limma rna-seq multiple factor design model-matrix written 20 months ago by smurray10 • updated 20 months ago by Aaron Lun23k

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