## User: nikosbosse

nikosbosse •

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#### Posts by nikosbosse

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... Thanks a lot for your explanations
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written 4 months ago by
nikosbosse •

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... I understand. That helped a lot. So I can take the mean of the normalized counts for estimating mu_ij and later for estimating log q_ij = X_j* beta_i, q_ij are just the normalized counts, right?
Thanks!
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written 4 months ago by
nikosbosse •

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... ah yes that could be a reasonable approach for a practical implementation.
But for the purpose of really understanding how DESeq2 works internally, could you maybe please explain to me how DESeq2 manages to obtain those intial estimates hat-mu_ij?
I tried to extract this information from the sourc ...

written 4 months ago by
nikosbosse •

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... Thank you very much for taking the time to answer and your kind and thorough reply. I very much appreciate it.
I'm not quite sure yet what approach would suit me best as I am just beginning to work with Bayesian models in general and Differential Gene Expression in particular. So my idea was, just ...

written 4 months ago by
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... side question from a newbie: is there a way to use something like LaTeX or MathML to format this post? My attempts so far failed..
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written 4 months ago by
nikosbosse •

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... Please excuse if this is not the right place to post this question. I am trying to wrap my head around the exact details of the DESeq2 method in order to reimplement a simplified version of it in Stan for training purposes.
At the moment I am struggling to grasp how means for the negative binomial ...

written 4 months ago by
nikosbosse •

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