User: nikosbosse

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nikosbosse0
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Posts by nikosbosse

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Comment: C: Statistical background for computing intial estimates for the means of negative
... Thanks a lot for your explanations ...
written 10 weeks ago by nikosbosse0
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Comment: C: Statistical background for computing intial estimates for the means of negative
... I understand. That helped a lot. So I can take the mean of the normalized counts for estimating mu_ij and later for estimating log q_ij = X_j* beta_i, q_ij are just the normalized counts, right? Thanks! ...
written 10 weeks ago by nikosbosse0
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Comment: C: Statistical background for computing intial estimates for the means of negative
... ah yes that could be a reasonable approach for a practical implementation. But for the purpose of really understanding how DESeq2 works internally, could you maybe please explain to me how DESeq2 manages to obtain those intial estimates hat-mu_ij? I tried to extract this information from the sourc ...
written 10 weeks ago by nikosbosse0
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Comment: C: Statistical background for computing intial estimates for the means of negative
... Thank you very much for taking the time to answer and your kind and thorough reply. I very much appreciate it.  I'm not quite sure yet what approach would suit me best as I am just beginning to work with Bayesian models in general and Differential Gene Expression in particular. So my idea was, just ...
written 10 weeks ago by nikosbosse0
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Comment: C: Statistical background for computing intial estimates for the means of negative
... side question from a newbie: is there a way to use something like LaTeX or MathML to format this post? My attempts so far failed.. ...
written 10 weeks ago by nikosbosse0
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Statistical background for computing intial estimates for the means of negative binomially distributed gene counts in DESeq2
... Please excuse if this is not the right place to post this question. I am trying to wrap my head around the exact details of the DESeq2 method in order to reimplement a simplified version of it in Stan for training purposes.  At the moment I am struggling to grasp how means for the negative binomial ...
deseq2 design matrix written 10 weeks ago by nikosbosse0

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