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Posts by ferranpauls10
Comment: C: GENESIS: ascertainment in GWAS
... Yes, but I think it's different of what I really want. Ascertainment bias is adjusted by conditioning the likelihood of each family by the proband, which in my case is only only one individual. If I do as you say, the variance of each family would be adjusted by all the probands at the same time, ...
... Hi, I'm using GENESIS package to do a GWAS and it works fine, but my dataset is based on families, which were ascertained by one individual each and I would like to know how to control this bias. fitNullModel function allows you to adjust the model by a kinship matrix and a household membership ma ...
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