User: chenggyan

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chenggyan0
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Dispersion shrinkage in DESeq2: LOESS instead of negative binomial based GLM?
... DESeq2 uses GLM with negative binomial distibution to shrink variance. It seems that GLM is used because the expression variance is different for gene with different expression level and a ordinary linear model is not suited. I am wonder if it is possible to model this regressor using LOESS instead ...
deseq2 rna-seq written 7 days ago by chenggyan0 • updated 7 days ago by Michael Love25k

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