User: Moritz Hess

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Moritz Hess60
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60
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5 years, 9 months ago
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6 years, 2 months ago
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Posts by Moritz Hess

<prev • 6 results • page 1 of 1 • next >
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Comment: C: Proper set up to test interaction of continuous covariate and factor levels (lim
... Hi James, thanks for your reply! My intention to use the above mentioned (although improper as you mentioned) method was to be able to form clear tests. I assumed that when I am testing for genes responding to the covariate e.g. significant "cov" I am testing against the Baseline in the reference ...
written 5.8 years ago by Moritz Hess60
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Proper set up to test interaction of continuous covariate and factor levels (limma)
... Hi, I am investigating the global gene expression response to a continuous environmental covariate in two groups of individuals using limma. I am interested in genes whose expression is: A) correlated with the covariate B) differentially correlated with the covariate in the two groups of individual ...
limma written 5.8 years ago by Moritz Hess60 • updated 5.8 years ago by James W. MacDonald50k
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Comment: C: Limma\'s roast() does not accept weigths in combination with block
... Hi Gordon, thanks for your response. I appreciate very much to hear that this feature will be implemented in future releases of limma. Best regards, Moritz 2013/8/6 Gordon K Smyth > Date: Mon, 5 Aug 2013 03:36:49 -0700 (PDT) >> From: "Moritz Hess [guest]" >> To: bioconductor@ ...
written 5.9 years ago by Moritz Hess60
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Comment: C: [Bioc] RNAseq less sensitive than microarrays? Is it a statistical issue?
... Hi Lucia, I know this post is a little bit redundant to Simons Post but I would also think that it's worth checking logFC and mean Expression Values of the Microarray DE transcripts that have not been flagged as DE by RNA-Seq and maybe as Simon stated, technical noise is just too large to overcome ...
written 6.1 years ago by Moritz Hess60
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Comment: C: need help for the study design of a RNA-Seq project
... Hi Shirley, I would say it depends. If you are investigating an organism with no good transcriptomic or genomic sequence ressources, I would also recommend 100bp PE because for a subsequent assembly of the reads this is for shure beneficial. If you have plenty of genomic ressources available, I wou ...
written 6.2 years ago by Moritz Hess60
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Comment: C: Testing for no change in RNA-seq data?
... Hi capricy, as far as I now, limma output and edgeR do behave differentially in what you stated, that limma also calculates a moderated F-value similarly as in standard linear models. But i assume (not 100% shure about it) that when using a GLM, conducting a F test is not possible because your resi ...
written 6.2 years ago by Moritz Hess60

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