User: Hilary

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Hilary20
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United States
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3 years, 7 months ago
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Posts by Hilary

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Comment: C: Limma time series spline help
... Thank you again; you have been very helpful! Because the 12 timepoints are repeated measurements on each of the 14 subjects (12*14 for 168 arrays), I assume it is necessary to use blocking based on the post in https://support.bioconductor.org/p/70070/. I will be sure to plot the genes and use this t ...
written 3.6 years ago by Hilary20
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Comment: C: Limma time series spline help
... Thank you very much. This is very helpful. I have a couple more questions, and especially am hoping you wouldn't mind scanning my contrasts (coef) setup below to see if I correctly interpreted what you said. Mainly I'm uncertain of my setup because I typically am able to make one contrasts matrix fo ...
written 3.6 years ago by Hilary20
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Limma time series spline help
... I have been reviewing the R/limma manual (esp. sections 9.6.1 and 9.6.2), and need conceptual help in applying this. In brief, I have a time serise with 12 Times(unevenly spaced), and for my Treatment I have 6 replicate Control individuals plus 8 replicate Affected individuals (14 people total, wit ...
limma design and contrast matrix covariate spline written 3.6 years ago by Hilary20 • updated 3.6 years ago by Aaron Lun23k

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Popular Question 3.6 years ago, created a question with more than 1,000 views. For Limma time series spline help

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