Dealing with technical replication with a common reference design
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@gordon-smyth
Last seen 25 minutes ago
WEHI, Melbourne, Australia
At 08:43 PM 12/09/2005, michael watson \(IAH-C\) wrote: >Thanks Gordon > >When I called duplicateCorrelation, I got three warning messages: > >Too much damping - convergence tolerance not achievable in: glmgam.fit( >etc etc) > >My corfit$consensus was then positive, even though it is a dye-swap >experiment. Presumably this means I don't have to treat the technical >replicates in any special way...? > >Mick That would be my interpretation, if everything else is correct. Technical variation often dominates biological. If the correlation is much larger than zero however, something is wrong. Gordon
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