I just installed the latest version of R (2.2.0) and reinstalled and updated limma. When I ran duplicateCorrelation I got the following warning (presumably 22500 times). 'randomizedBlockFit' is deprecated. Use 'mixedModel2Fit' instead. Naomi S. Altman 814-865-3791 (voice) Associate Professor Dept. of Statistics 814-863-7114 (fax) Penn State University 814-865-1348 (Statistics) University Park, PA 16802-2111