Dear all, on a slightly off-topic note: We have been using our own set of R routines for microarray analysis for a year or so. Inspired by the tutorials at the DSC in Vienna last month, I have decided that we should use library(annotate) forthwith. For the HGU133A-chip, we have been using a gene info file downloaded from the DChip site with date 12th of March, 2002 up to now. When comparing the LocusLink IDs there with those provided by hgu133aLOCUSID (Version 1.1.1., 19th of Februray 2003), I found about 4% (~900) more annotations in the BioConductor package (good!), but also about 1% (> 200) explicit mismatches. Even given that this is an extremely dynamic area etc., I'm somewhat worried whether this is actually possible. Does this much change in less than a year sound realistic to list members, or should I start bug hunting? Thank you! alexander Alexander.Ploner@mep.ki.se Phone: 46-8-728 6858 Fax : 46-8-314975 Department of Medical Epidemiology Karolinska Institutet, P.O. Box 281, SE-171 77 Stockholm