Hello all, I've found an issue in your limma package concerning read.maimages First there appears to be two different latest versions out there CRAN has limma 2.4.7 and bioconductor has 2.2.0 is 2.4.7 still experimental or has bioconductor just not been updated. Issue with read.maimages, wt.fun no longer works. Since read.table is now using colClasses you include wt.fun in its creation which is a function and not a column and therefore error outs. Possible fixes could include removing colClasses entirely and read.table reads in all columns, or Remove wt.fun from colClasses creation and require user to include all columns found in wt.fun in other.columns, or Its your program do whatever you want Just thought you'd like to know Matt Settles University of Idaho Department of Bioinformatics and Computational Biology