Genbank accessions for GOstuff
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adlai burman ▴ 50
@adlai-burman-1025
Last seen 10.3 years ago
The GO packages seem to rely solely on LocusLink ids but there are a host of onboard affy translators. Now LL seems to be deprecated and I don't use affymetrix. I have thousands of genes which I would love to continue using with BioC. Does anyone know of a mapping somewhere where I can batch convert gb nums or gene symbols in a way that R's GO packages will accept. Thanks in advance. AB
GO affy convert GO affy convert • 1.1k views
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@sean-davis-490
Last seen 4 months ago
United States
On 8/9/06 3:02 AM, "adlai burman" <fsajb4 at="" uaf.edu=""> wrote: > The GO packages seem to rely solely on LocusLink ids but there are a > host of onboard affy translators. Now LL seems to be deprecated and I > don't use affymetrix. Locuslink has simply been replaced by Entrez Gene. For nearly all intents and purposes, Locuslink still exists, but has the name Entrez Gene. So, when you read about Locuslink-based analyses, these are still appropriate and possible. > I have thousands of genes which I would love to > continue using with BioC. Does anyone know of a mapping somewhere where > I can batch convert gb nums or gene symbols in a way that R's GO > packages will accept. Thanks in advance. The AnnBuilder package is the way to build an annotation package for your genes. It takes genbank ids and makes an annotation package for your array that you can then use for downstream analyses. Alternatively, there are several online resources that allow you to do GO analyses using genbank IDs. For example, the DAVID/EASE system (http://david.niaid.nih.gov/david) supports genbank IDs as input. Finally, there are tools to convert your genbank accessions to more useable IDs, like Entrez Gene (Locuslink) IDs. For example, Stanford Source ( http://source.stanford.edu/cgi-bin/source/sourceSearch) can convert between genbank IDs and multiple gene identifiers. Sean
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Also note that you can easily map your GenBank IDs to GO IDs or a host of other IDs using biomaRt. Best, Jim Sean Davis wrote: > > > On 8/9/06 3:02 AM, "adlai burman" <fsajb4 at="" uaf.edu=""> wrote: > > >>The GO packages seem to rely solely on LocusLink ids but there are a >>host of onboard affy translators. Now LL seems to be deprecated and I >>don't use affymetrix. > > > Locuslink has simply been replaced by Entrez Gene. For nearly all intents > and purposes, Locuslink still exists, but has the name Entrez Gene. So, > when you read about Locuslink-based analyses, these are still appropriate > and possible. > > >>I have thousands of genes which I would love to >>continue using with BioC. Does anyone know of a mapping somewhere where >>I can batch convert gb nums or gene symbols in a way that R's GO >>packages will accept. Thanks in advance. > > > The AnnBuilder package is the way to build an annotation package for your > genes. It takes genbank ids and makes an annotation package for your array > that you can then use for downstream analyses. > > Alternatively, there are several online resources that allow you to do GO > analyses using genbank IDs. For example, the DAVID/EASE system > (http://david.niaid.nih.gov/david) supports genbank IDs as input. > > Finally, there are tools to convert your genbank accessions to more useable > IDs, like Entrez Gene (Locuslink) IDs. For example, Stanford Source ( > http://source.stanford.edu/cgi-bin/source/sourceSearch) can convert between > genbank IDs and multiple gene identifiers. > > Sean > > _______________________________________________ > Bioconductor mailing list > Bioconductor at stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor -- James W. MacDonald, M.S. Biostatistician Affymetrix and cDNA Microarray Core University of Michigan Cancer Center 1500 E. Medical Center Drive 7410 CCGC Ann Arbor MI 48109 734-647-5623 ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues.
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Nianhua Li ▴ 870
@nianhua-li-1606
Last seen 10.3 years ago
adlai burman <fsajb4 at="" ...=""> writes: > > The GO packages seem to rely solely on LocusLink ids but there are a > host of onboard affy translators. Now LL seems to be deprecated and I > don't use affymetrix. I have thousands of genes which I would love to > continue using with BioC. Does anyone know of a mapping somewhere where > I can batch convert gb nums or gene symbols in a way that R's GO > packages will accept. Thanks in advance. > > AB > Hi, adlai, ftp://ftp.ncbi.nlm.nih.gov/gene/DATA/gene2accession.gz gives GenBank to Entrez Gene mapping ftp://ftp.ncbi.nlm.nih.gov/gene/DATA/gene_info.gz gives gene symbol to Entrez Gene mapping GO package gives the GO to Entrez Gene mapping even though the environment name is GOLOCUSID. It will be fixed in next release. However, I think biomaRt is much more handy for your case. HTH nianhua
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