Few clarifications on the mixture model
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@aashish-dattani-2215
Last seen 11.1 years ago
Hi, I have been going through the paper on "ESTIMATING GENOME-WIDE COPY NUMBER USING ALLELE SPECIFIC MIXTURE MODELS". I am clear with everything till the point where all the parameters in equation (2) involving parameters for all copy numbers have been calculated. But after that it has been said that: "With the parameter estimates in place we are able to provide posterior probabilities for allele specific copy number. Furthermore, we can compute these posterior probabilities for copy number: ...." (section 4) How are they to get the conditional probabilities from the parameter estimates? Arent they just of the units of the signal intensity? And where are they using them if at all? I am doing this as a part of a project where i will implement this algorithm. Can you please atleast give me a brief algorithmic view by clearing my doubt about this part. I'll be very grateful. Thanking you, Aashish Dattani.
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