Hi Joao, The STAC method may help you (http://cbil.upenn.edu/STAC/). If you want to combine the results from the 3 algorithms, the Fisher method can be used to combine the p-values obtained from STAC in each region and each algorithm. Pingzhao ======================================== Pingzhao Hu Statistical Analysis Facility The Centre for Applied Genomics (TCAG) The Hospital for Sick Children Research Institute MaRS Centre - East Tower 101 College Street, Room 15-705 Toronto, Ontario, M5G 1L7, Canada Tel.: (416) 813-7654 x6016 Email: phu at sickkids.ca Web: http://www.tcag.ca/statisticalAnalysis.html