A researcher here would like to analyze data that is in the ABF format in R without using another tool (e.g. Origin Pro) to convert from ABF to a TXT file. FWIW: "The ABF file format has been used for many years by Axon Instruments for the pCLAMP electrophysiology data acquisition and analysis software." "The AXON BINARY FILE format (ABF) was created for the storage of binary experimental data. It originated with the pCLAMP suite of data acquisition and analysis programs, but is also supported by AxoTape and AxoScope." I haven't found any R/Bioconductor hits about ABF, but thought someone might know if anyone has already written code to read ABF files in R? I have some documentation from Molecular Devices (they apparently bought Axon) about the ABF and ABF2 file formats, including an ABF2 Programmer's Guide that was revised in Oct 2007, but didn't want to have this "fun" if someone else has already written R code for this. efg Earl F. Glynn Scientific Programmer Stowers Institute for Medical Research