Hi, We recently released DAnTE (Data Analysis Tool Extension) a statistical tool with a GUI for the analysis of proteomics and genomics data under Apache license and thought the folks here would be interested. It is based on R and R(D)COM. GUI is written in C# and .NET. I am thankful to the various R mailing lists for the kind of information I got. The tool along with an example dataset with instructions on how to perform a series of analysis steps is available at http://omics.pnl.gov/software/DAnTE.php (Note: thoroughly tested on R 2.6.2). An application note on the tool is recently published in the Bioinformatics journal: "DAnTE: a statistical tool for quantitative analysis of-omics data" - Polpitiya, Ashoka; Qian, Weijun; Jaitly, Navdeep; Petyuk, Vladislav; Adkins, Joshua; Camp, David G.; Anderson, Gordon; Smith, Richard, Bioinformatics 24(3):1556-1558. Brief abstract: Data Analysis Tool Extension (DAnTE) is a statistical tool designed to address challenges associated with quantitative bottom-up, shotgun proteomics data. This tool has also been demonstrated for microarray data and can easily be extended to other high-throughput data types. DAnTE features selected normalization methods, missing value imputation algorithms, peptide-to-protein rollup methods, an extensive array of plotting functions and a comprehensive hypothesis-testing scheme that can handle unbalanced data and random effects. The graphical user interface (GUI) is designed to be very intuitive and user friendly. Thanks again for the great work by the R, R(D)COM and Bioconductor community. Ashoka Polpitiya --- Scientist Pacific Northwest National Laboratory Richland, WA, USA.