I eventually fixed this problem, but wondered, as a newbie to R, whether the error I had should have clued me into the fact that I didn't have the latest version of Biobase and its dependent packages, tkWidgets, genefilter, etc. Here's the error: > library(Biobase) Error in bindingIsLocked(m2, where) : not an environment Error in library(Biobase) : .First.lib failed > .packages(all.available = TRUE) [1] "base" "Biobase" "boot" "class" "cluster" "ctest" "eda" "foreign" [9] "genefilter" "grid" "KernSmooth" "lattice" "lqs" "MASS" "methods" "mgcv" [17] "mle" "modreg" "mva" "nlme" "nls" "nnet" "reposTools" "rpart" [25] "spatial" "splines" "stepfun" "survival" "tcltk" "tkWidgets" "tools" "ts" Warning message: package:Biobase is required by package:genefilter (still attached) in: detach(name = "package:Biobase") As you can see, it was in my search path. And I have yet to find a description of this error in the R archives, in general. I guess what I'm really asking is, what does "Error in bindingIsLocked(m2,where) : not an environment " mean? And is there anything in the explanation of that error that tells someone that they have a versioning issue with the package and R? Thanks!!! -Scott [[alternative HTML version deleted]]

> > > > library(Biobase) > > Error in bindingIsLocked(m2, where) : not an environment An error of this sort(*) typically indicates that there is a mismatch between the version of R being used and the version of Biobase (or any bioconductor package) being installed. Users of any version of R prior to 1.8.0 must refrain from using devel versions of bioconductor resources. You can get more information on bindingIsLocked through the standard R help facilities. Please, when you send transcripts like this, identify the specific version of R you are using, the specific OS platform, and the specific steps for installation that you used to trigger the error. (*) What does "of this sort" mean? Usually these errors involve functions that are remote from the user, involving environment bindings, class metadata etc. We will try to improve the diagnostic messages as the new release approaches.