Hi Dorothy, The Mouse 430A 2.0, Mouse 430 2.0, and MOE430A are different arrays. As I understand it, the hgu133plus2 and hgu133plus2.db packages contained the same information, only in different formats. But only the hgu133plus2.db format appears to be included in the current release (2.3) of Bioconductor. If you are asking whether there have been any changes in the annotations for the current release (2.3) compared to earlier releases, the annotations are always changing, ad you can expect differences of the order of maybe 5-10%, sometimes more, from one release to the next. That is because the underlying databases that are the sources of the annotations - EntrezGene, UniGene and RefSeq, for example - are constantly changing. Hope this answers your question. Regards, Maria