Hi! I am trying to install the onechannelGUI mainly for exon array analysis. I am using R 2.8.0. I have followed the instructions described in http://www.bioconductor.org/packages/2.4/bioc/html/oneChannelGUI.html When I try to load exon arrays appears the following error: Gene level probe sets summary started Read 10 cel files from: target5f906952 FATAL ERROR: .\TsvFile\TsvFile.cpp:2352: open: Could not open file: 'C:/PROGRA~1/R/R-28~1.0/library/oneChannelGUI/affylibs/' to read. Gene level probe sets summary ended Error in as.matrix(my.exons) : no function to return from, jumping to top level In addition: Warning messages: 1: In file(file, "r") : cannot open file 'C:/PROGRA~1/R/R-28~1.0/library/oneChannelGUI/affylibs/': Permission denied 2: In file(file, "r") : cannot open file 'C:/PROGRA~1/R/R-28~1.0/library/oneChannelGUI/affylibs/': Permission denied 3: In file(file, "r") : cannot open file 'E:/MCLi/CELfiles/out6df11649/': Permission denied I would appreciate your help, Best wishes, Pedro Pedro Jares, Ph.D. Pathology Department Hospital Clinic, University of Barcelona C/ Villarroel 170 08036, Barcelona, Spain [[alternative HTML version deleted]]