Hi: In sigPathways package, if I have characters for defining a pheno object, how is sigPathway treating the class labels based on pheno object. for example: my.pheno <- c('normal', 'cancer','normal','normal','cancer') now when I "runSigPathway" on the data matrix, how is sigPathway considers to computer t-statistic. Normal/cancer or cancer/normal. similarly, if I define binary vector for pheno class lable, is 1/0 considered or 0/1 considered. thank you. Ad