I have been trying to install bioconductor 2.5 packages using biocLite and keep receiving the following error message: package 'KEGG.db' successfully unpacked and MD5 sums checked package 'AnnotationDbi' successfully unpacked and MD5 sums checked Error in normalizePath(path) : path[1]="C:\Program Files\R\R-2.10.1\library/AnnotationDbi": The system cannot find the file specified In going through the archives, I found and tried this: Elliot Kleiman <kleiman at="" rohan.sdsu.edu="" <https:="" stat.ethz.ch="" mailman="" listinfo="" bioconductor="">> writes: >* Hi BioC, *>* *>* I am unable to install the new BioC 2.4 *>* as I am receiving the following error, * >* Error in normalizePath(path) : *>* path[1]="C:\Program Files\R\R-2.9.0\library/GO.db": The system cannot *>* find the file specified * Hi Elliot -- The R-help and R-devel lists suggest this might be related to anti-virus software, especially if the failure changes over time. One useful possibility is to say trace(normalizePath, quote(cat("path=", path, "\n"))) before biocLite(). You'll see the arguments called each time normalizePath() is invoked, and it'll likely rule out a number of possibilities, e.g., spaces in the path name or use of \ and / HTH, Martin I tried the solution and am not sure what to do with it. Here is the recent attempt: Tracing normalizePath(lib) on entry path= C:/PROGRA~1/R/R-210~1.1/library package 'AnnotationDbi' successfully unpacked and MD5 sums checked Tracing normalizePath(file.path(tmpDir, curPkg)) on entry path= C:\Program Files\R\R-2.10.1\library\file54de1547/AnnotationDbi Tracing normalizePath(instPath) on entry path= C:\Program Files\R\R-2.10.1\library/AnnotationDbi Error in normalizePath(path) : path[1]="C:\Program Files\R\R-2.10.1\library/AnnotationDbi": The system cannot find the file specified Thanks for any help or suggestions! -- Eric Bremer, PhD Chief Scientific Officer Precision Biomarker Resources, Inc. 820 Davis St., Suite 216 Evanston, Illinois 60201 Office: 847.866.0406 Mobile: 708.267.2052 Skype: egbremer www.precisionbiomarker.com [[alternative HTML version deleted]]