Hi, I'm currently doing a study using Affymetrix GeneChip Human Gene 1.0 ST v1. I have a batch of 8 arrays from the first batch and 20 arrays from the second batch. When i look at the density plot of the log2 of the intensity values before preprocessing, there seems to be a bump small bump in the higher intensity range. I'm under the impression that this means there is saturation of the chips and I will need to either filter or process the data before further analysis. I can't seem to find any information on how to procede in my analysis. Any experience or insight would be greatly appreciated. Dennis [[alternative HTML version deleted]]