I'm passing this around the bioinformatics community as I think it's an interesting initiative. A British bioinformatician wants to open discussion about the greatest biological discovery made possible by bioinformatics. He has just launched a "brainstorming competition" with a small cash prize to stoke discussion. Kaggle is hosting the "brainstorming competition" at: http://kaggle.com/blog/2010/06/17/%EF%BB%BFwhat-has-bioinformatics- ever-done-for-us Hopefully members of this mailing list can contribute suggestions. Anthony ps Apologies for cross posting.