Dear list: I know this has been discussed before, but I can't open the link to the Bioconductor Archives. My question is regarding the key system requirements to be able to "comfortably" analyze Affy cel files. The bottleneck on my machine (more like a dead end) is trying to run bg.adjust.gcrma(). I'm running Windows 2000, on a Pentium 4 CPU 1.80GHz with 526M of RAM. Is there informed opinion on the relative importance of the various factors? Operating system: Windows vs Linux/Unix? Speed of Processor? Memory capacity? Other factors? Thanks -francois [[alternative HTML version deleted]]