I agree with Vince about posting to R-help. However, if you have individual P-values, I am not sure why you cannot do a ordinary meta-analysis combining p-values using Fisher's method. There is not an R package to do this, but it would simply involve calculating T = -2*log(p-value1)-2*log(p-value2)-...-2*log(p-valuem) where m is the number of p-values. Under the null hypothesis, this will be distributed as chi-squared with m degrees of freedom, so you would then do T.pval = 1-pchisq(T,m) to get the combined p-value. HTH, Debashis On Wed, Jul 14, 2010 at 11:01 PM, Vincent Carey <stvjc at="" channing.harvard.edu=""> wrote: > This is really a question for R-help. ?However, rmeta could be used if > you knew the study effect sizes and standard errors (see > meta.summaries). ?Under certain assumptions you would be able to > derive a standard error for a given estimate from a p-value and sample > size. > > On Wed, Jul 14, 2010 at 3:55 PM, Laura Rodriguez Murillo > <laura.lmurillo at="" gmail.com=""> wrote: >> Hi dear list, >> >> My question is on meta-analysis. I have three studies on the association of >> a SNP with a disease and I need to do a random-effects meta- analysis with my >> data. I only have the individual P value, the odds ratio and sample size >> from each study. I've checked rmeta and meta packages but it seems to me >> that I need to know the number of observations on each group, which I don't >> have in this case. Is there any other package I can use that accepts doing >> meta-analysis with these data? >> >> Thanks a lot for your help! >> >> Laura >> >> ? ? ? ?[[alternative HTML version deleted]] >> >> _______________________________________________ >> Bioconductor mailing list >> Bioconductor at stat.math.ethz.ch >> https://stat.ethz.ch/mailman/listinfo/bioconductor >> Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor >> > > _______________________________________________ > Bioconductor mailing list > Bioconductor at stat.math.ethz.ch > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor > -- Debashis Ghosh Departments of Statistics and Public Health Sciences Penn State University University Park, PA 16802 works.bepress.com/debashis_ghosh/