GEO: Finding up- and down-regulated genes in GDS records
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Voke AO ▴ 760
@voke-ao-4830
Last seen 9.7 years ago
Hi, I don?t even know if this is remotely possible but I just thought I should take a chance. On the GDS record pages in GEO, there is an analysis tools button. Clicking on this gives the option of finding genes that are up/down for the condition in the dataset, I believe. The result however does not indicate which is up or down regulated...at least I can?t seem to find where it shows that. Is it possible to somehow retrieve this information on up- and down- regulated genes in with R? Thanks. Avoks
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@sean-davis-490
Last seen 4 months ago
United States
There is not a way to get this information from R or from the website, for that matter. That said, you can download the data and perform local calculations using R. See the GEOquery package for the "download" part and the limma package, for example, for the analysis side of things. Sean On Fri, Sep 16, 2011 at 9:59 AM, Ovokeraye Achinike-Oduaran <ovokeraye at="" gmail.com=""> wrote: > Hi, > > I don?t even know if this is remotely possible but I just thought I > should take a chance. ?On the GDS record pages in GEO, there is an > analysis tools button. Clicking on this gives the option of finding > genes that are up/down for the condition in the dataset, I believe. > The result however does not indicate which is up or down > regulated...at least I can?t seem to find where it shows that. Is it > possible to somehow retrieve this information on up- and down- > regulated genes in with R? > > Thanks. > > Avoks > > _______________________________________________ > Bioconductor mailing list > Bioconductor at r-project.org > https://stat.ethz.ch/mailman/listinfo/bioconductor > Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor >
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Thanks Sean. I just realized that I hadn't acknowledged your response. My apologies. Thanks again. Avoks On Fri, Sep 16, 2011 at 6:31 PM, Sean Davis <sdavis2 at="" mail.nih.gov=""> wrote: > There is not a way to get this information from R or from the website, > for that matter. ?That said, you can download the data and perform > local calculations using R. ?See the GEOquery package for the > "download" part and the limma package, for example, for the analysis > side of things. > > Sean > > > On Fri, Sep 16, 2011 at 9:59 AM, Ovokeraye Achinike-Oduaran > <ovokeraye at="" gmail.com=""> wrote: >> Hi, >> >> I don?t even know if this is remotely possible but I just thought I >> should take a chance. ?On the GDS record pages in GEO, there is an >> analysis tools button. Clicking on this gives the option of finding >> genes that are up/down for the condition in the dataset, I believe. >> The result however does not indicate which is up or down >> regulated...at least I can?t seem to find where it shows that. Is it >> possible to somehow retrieve this information on up- and down- >> regulated genes in with R? >> >> Thanks. >> >> Avoks >> >> _______________________________________________ >> Bioconductor mailing list >> Bioconductor at r-project.org >> https://stat.ethz.ch/mailman/listinfo/bioconductor >> Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor >> >
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