Dear all, the focus of my analyses is with the activation of immune related pathways. I routinely use GO analysis, KEGG pathways and SPIA (which is also based on KEGG). However, the number of immune pathways in KEGG is limited, for example compared with Ingenuity or GeneGO. However, even though I have access to Ingenuity, I have three problems with it: (i) does not integrate well with R, which is my primary tool (ii) does not work with Linux, which is my OS and (iii) is commercial, so that not every scientist can repeat my observations. What would you recommend in lieu of Ingenuity for immunological analyses? Is there a replacement? Or, if there isn't, would anyone be interested in such an immune system oriented database / collection of pathways that could be used from R? kind regards, j. -- -------- Dr. January Weiner 3 --------------------------------------