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Haiyan Wu
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10
@haiyan-wu-729
Last seen 10.5 years ago
Look for reference about paired analysis about microarray.
I have a data set about a microarray experiment for same patients
before and
after treatment. Data Layout is show in belwo
Table 1
Patient 1 Before surgery Patient 1 after surgery
Patient 2
Before surgery Patient 2 after surgery ..
Gene 1
Gene 2
.
.
The question of interest is to compare results before and after
treatment
and thus identify genes of interest, classify patients, and identify
patients who respond to the surgery. Also, the sample size needed for
further experiment is of interest. Typical statistical method would be
paired t test. But I don't know how to take account the correlation
between
genes and how to adjust for the false discovery rate.
I looked at some references. But they're either about independent
sample
groups or about complex time series using Markov Chains or Bayesian.
Is
there any reference for this type of experiment? Does Bioconductor
have a
package for this type of analysis?
I'm familiar with statistical method and bioconductor software. But
I'm
still new to microarray analysis. Any reply is sincerely appreciated.
Haiyan
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