I would like to take this opportunity to introduce myself. I am currently working on analyzing Illumina 450k Methylation Array dataset using minfi Package. I got the following error message while I call the dmpFinder function: dmp <- dmpFinder(mset, pheno=pd$Sample_Group, type="categorical") Error in smooth.spline(lambda, vec.p0, w = ncs.weights, df = 3) :   missing or infinite values in inputs are not allowed In addition: Warning messages: 1: Partial NA coefficients for 44 probe(s) 2: In pf(q, df1, df2, lower.tail, log.p) : NaNs produced I have traced out the error message and found that some missing values in my dataset: > sumis.na(getM(RGset))) [1] 28 Could you please advise how can I removed these missing values records from the dataset (i.e., RGset <- read.450k.exp (base = baseDir, targets = targets))? Regards, Haroon [[alternative HTML version deleted]]