Dear Bioconductor users and developers, we are pleased to announce new release of package "triplex" aimed at searching DNA sequences for nucleotide patterns capable of forming H-DNA (intramolecular triplexes). Through the last development cycle we worked on a clarification of P-value estimation to ensure reliable results, speed optimization (up to 3x faster algorithm) and scoring tables customization to meet your special needs. We would be greatful for any feedback, since the package is still quite new and we have very little experience with its use, apart from our own. Also, if package maintainers and developers see any issues in communicating between their packages and "triplex", we would like to hear about those. Happy searching, J.Hon, T.Martinek and M.Lexa