Hi, I was trying to process my 27k data, mainly trying to filter the probes with SNPs. After using IMA.methy450R to read in the data, I successfully created an exprmethy450 object, then I followed the instruction load("annot27k_mapped.RData") data@annot = as.matrix(annotout) Then use IMA.methy450PP to process the data, however, I found the following err msg: Error in read.table(file = file, header = header, sep = sep, quote = quote, : 'file' must be a character string or connection Any one has any clue on this? Thanks a lot! -Jack [[alternative HTML version deleted]]