I have a 20 samples with mutations ranging from 50 to 144 to extract signatures. I don't find an inflection point to determine rank. It seems like the more ranks I use the "better" fit. i suppose with the small number of samples i have there really can't be more than 2 or 3 signatures. Also as i look at the samples contributing to the signatures, some have multiple similar signatures.
Just to clarify, you have 20 different samples where the number of mutations per sample ranges from 50 to 144?
Correct, 20 different samples.