Dear all, I've recently completed a wrapper around Affymetrix's PLIER SDK. You'll find it in the developmental branch of BioConductor (listed as 'plier'). There also some details of how it was tested, etc. on our website at: http://bioinformatics.picr.man.ac.uk/plier/index.jsp Good luck! :-) Cheers, Crispin -------------------------------------------------------- This email is confidential and intended solely for the use o...{{dropped}}