Hi,

HiCDCPlus looks like a very useful tool and I am hoping to apply it to my HiChIP data. However, my data was generated using the Dovetail Genomics kit. Dovetail uses an MNase to fragment the DNA, so there are no sequence specific cut-sites thus I am. not sure if I can use the construct_features tool in a sensible way for my data type.

I'm wondering if there is any way to run "construct_features()" without the "sig = " argument for the cut sites. I notice that it runs with a default cut-site of GATC.

Thanks in advance for any advice!