Hello, I have been having issues with DESeq2 aborting at the differential expression stage after I upgraded the OS, RStudio and R on my Mac. The issue is not with memory, as other programs run fine. Any help much appreciated.

dds <- DESeq(dds)

#At the getting gene wise dispersion estimates stage - "R encountered a fatal error and needs to abort"

sessionInfo( )

R version 4.3.2 (2023-10-31)
Platform: aarch64-apple-darwin20 (64-bit)
Running under: macOS Big Sur 11.7.10

Matrix products: default
BLAS:   /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib 
LAPACK: /Library/Frameworks/R.framework/Versions/4.3-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.11.0

Random number generation:
 RNG:     Mersenne-Twister 
 Normal:  Inversion 
 Sample:  Rounding 

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

time zone: Europe/London
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

loaded via a namespace (and not attached):
[1] compiler_4.3.2 tools_4.3.2

Havent seen this before.

Try reinstalling DESeq2.

If that doesnt work try reinstalling Rcpp as well.