help

I've been given an RNA count matrix and metadata files and asked to do differential expression analysis and when I inspected the data found that the count matrix contained decimal values and DESeq2 can't process it, so how to solve this knowing that I don't have any further information about the data how it's processed.,

the data is not normalized nor log transformed

You could do what DESeq2 does with e.g., decimal counts from tximport, which is to change the mode to "integer".

## assuming your decimal counts are in a matrix called 'counts'
mode(counts) <- "integer"
dds <- DESeqDataSetFromMatrix(counts, <other args go here>)