Hi, I made and miRNA seq experiment and I'm analyzing it. I generated a miRNA counting table based on mirbase (v22). The problem is that hundreds of miRNAs had 0 counts in all samples, and I don't know if I should remove them before DESeq2 analysis. In my opinion, those miRNAs should be excluded before analysis, since they can impact in the adjusted p-value (I guess), but I'm not sure what to do. Anybody knows the right way to deal with this type of data and how to analyze them? Thanks