If you have a .xls file, it is probably the MAS5 normalized data. You should open the file under Excel before importing into Bioconductor, and make sure you understand what you have. Much of what you will read about normalization assumes that you are starting with unnormalized probe- level data. --Naomi At 11:24 AM 6/27/2005, Cecilia Fernandez wrote: >Hi! >I have Affimetrix data, but I don't have .CEL files, only a .xls. >How can I open this file with Bioconductor? >Thank you. > >_______________________________________________ >Bioconductor mailing list >Bioconductor at stat.math.ethz.ch >https://stat.ethz.ch/mailman/listinfo/bioconductor Naomi S. Altman 814-865-3791 (voice) Associate Professor Bioinformatics Consulting Center Dept. of Statistics 814-863-7114 (fax) Penn State University 814-865-1348 (Statistics) University Park, PA 16802-2111