Hi, I am trying to install the R libraries "rmutil" and "repeated" on a Mac OS X version 10.4.1 (which has the latest version of the Mac Developer tools installed) and I am having trouble compiling the libraries. The error message I receive is as follows (I have only included the error message when I try and install the rmutil library): ............................ * Installing *source* package 'rmutil' ... ** libs gcc-3.3 -no-cpp- precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c cutil.c -o cutil.o gcc-3.3 -no-cpp-precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c dist.c -o dist.o g77 -fno-common -g -O2 -c gettvc.f -o gettvc.o gcc-3.3 -no-cpp-precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c romberg.c -o romberg.o gcc-3.3 -no-cpp-precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c toms614.c -o toms614.o gcc-3.3 -bundle -flat_namespace -undefined suppress -o rmutil.so cutil.o dist.o gettvc.o romberg.o toms614.o -L/usr/local/lib/gcc/powerpc-apple-darwin6.8/3.4.2 -lg2c -lSystem package successfully installed ld: dist.o has external relocation entries in non-writable section (__TEXT,__text) for symbols: restFP saveFP make: *** [rmutil.so] Error 1 ERROR: compilation failed for package 'rmutil' ...................... When I remove the makefile (as suggested on Jim Lindsey's website) and try again, I get the following similar (but slightly different) output. ...................... * Installing *source* package 'rmutil' ... ** libs gcc-3.3 -no-cpp- precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c cutil.c -o cutil.o gcc-3.3 -no-cpp-precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c dist.c -o dist.o g77 -fno-common -g -O2 -c gettvc.f -o gettvc.o gcc-3.3 -no-cpp-precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c romberg.c -o romberg.o gcc-3.3 -no-cpp-precomp -I/Library/Frameworks/R.framework/Resources/include -I/usr/local/include -fno-common -g -O2 -c toms614.c -o toms614.o gcc-3.3 -bundle -flat_namespace -undefined suppress -L/usr/local/lib -o rmutil.so cutil.o dist.o gettvc.o romberg.o toms614.o -L/usr/local/lib/gcc/powerpc-apple-darwin6.8/3.4.2 -lg2c -lSystem -framework R ** Removing '/Library/Frameworks/R.framework/Versions/2.1.1/Resources/library/rmut il' ** Restoring previous '/Library/Frameworks/R.framework/Versions/2.1.1/Resources/library/rmut il' package successfully installed ld: dist.o has external relocation entries in non-writable section (__TEXT,__text) for symbols: restFP saveFP make: *** [rmutil.so] Error 1 ERROR: compilation failed for package 'rmutil' ........................ I contacted Jim Lindsey (the package author) who wasn't able to suggest a solution. Hence, does anyone have an idea what could be causing this error or does anyone have a Mac binary for these libraries? Thanks, John Marioni PS I know that these packages are not part of bioconductor, but they are pre-requisites for running the aCGH package of Jane Fridlyand. Hence, I thought it was appropriate to post this message (which I also sent to the R mailing list). -- John Marioni PhD Student Computational Biology Group Department of Applied Mathematics and Theoretical Physics University of Cambridge Wilberforce Road, Cambridge, CB3 0WA Email: J.Marioni at damtp.cam.ac.uk Phone: +44 (0)1223 763391