## User: Seymoo

Seymoo0
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#### Posts by Seymoo

<prev • 28 results • page 1 of 3 • next >
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... I have noticed that when I apply NMF to log2 transformed gene expression data for classification purpose the result are different than if I first do an exponential transformation of the same data matrix. Also, test statistics increase after exponential transformation. I know that NMF is not applica ...
written 10 months ago by Seymoo0
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... I am wondering how to make a silhouette plot on the results from Mclust packge, where measure of silhouette for each sample in each group is shown? Using "Fcp" package I can check the average silhouette. mb = Mclust(iris[,-5], 3) cs = cluster.stats(dist(iris[1:4]), mb\$classification) #instal ...
written 13 months ago by Seymoo0
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Comment: C: limma contrast matrix
... Hi @Aaron Lun . I didnt want to post a new question because I am actually a bit confused with the reversing that you just mentioned above ( e.g., N50_C - N50_D instead of N50_D - N50_C ), because by doing so this can swap the number of detected DE. I am wondering if what is generally accepted when I ...
written 13 months ago by Seymoo0
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... Thanks James! ...
written 14 months ago by Seymoo0
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... I want to use camera function in limma. I downloaded xml file from MSigDB and loaded it but I am wondering how can I make it to a compatible list for camera function as it has been mentioned in here that GEneCollection need to be converted to a list. what I have done is gsc <- getBroadSets(" ...
written 14 months ago by Seymoo0 • updated 14 months ago by James W. MacDonald49k
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... I have a gene expression data AllExp and a data.frame info with sample name of AllExp as row names and first column in it specifies groups that each sample belongs to. I am trying to perform a a gene set enrichment analysis using GSA package. but I get following error `Error in cut.default(s ...
written 14 months ago by Seymoo0
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... @saibar Hi Sara, Thanks for making this great package. I am wondering if you add cost argument in the formula to be set by users or if you could explain how to modify it the way it is right now ? I am using Caret package to find optimal cost to be used in the function and I would like to adjust co ...
written 16 months ago by Seymoo0
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... Thanks a lot for explanation @Aaron Lun. ...
written 16 months ago by Seymoo0
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... Hi James, So because now I am comparing them against the mean, to do similar comparison would it be better to formulate it like this cm1 <- makeContrasts(G1VsG2 = G1-G2, G1VsG3 = G1-G3, G1VsG4 = G1-G4, G2VsG3 = G2-G3, ...
written 16 months ago by Seymoo0
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... In a cohort of cancer samples there are 4 groups, G1 to G4. I want to perform differential gene expression between group1 Vs all other groups, i,e, G1 = G1-(G2+G3+G4)/3, to determine DEGs for group 1. I could just find an example in limma guide where pair-wise comparisons being made ( under 9.3. se ...
written 16 months ago by Seymoo0 • updated 16 months ago by James W. MacDonald49k

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