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User: flippy23

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flippy230
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Posts by flippy23

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Comment: C: paired sample - SVA model matrix
... Got it. I just want to ensure that I'm accounting for blocking correctly in the full model. I wouldn't include study_id in the null model because differences between the patients isn't something I want to account. Likewise, wouldn't include treatment effect in the null model because that's what I'm ...
written 8 weeks ago by flippy230
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Comment: C: paired sample - SVA model matrix
... So...just to make sure I understand. null model (only adjustment covariates) would consist of: covariate 1 + covariate 2 + covariate 3  full model: ~Study_ID+Treatment + covariate 1 + covariate 2 + covariate 3    how will it differentiate the treatment effect from the other covariates?    ...
written 8 weeks ago by flippy230
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paired sample - SVA model matrix
... Hello,   I am running SVA and had a question regarding the null and full model matrices. I am comparing a before/after effect of a treatment within each patient. How do I account for this in building the model matrices? How do I specify to SVA that the before/after variable is within the same pati ...
limma sva paired sample written 8 weeks ago by flippy230 • updated 8 weeks ago by James W. MacDonald49k

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