User: Nikos Ignatiadis

Reputation:
130
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Trusted
Location:
Heidelberg
Last seen:
4 days, 5 hours ago
Joined:
2 years, 9 months ago
Email:
n*****************@gmail.com

Posts by Nikos Ignatiadis

<prev • 7 results • page 1 of 1 • next >
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Answer: A: Anomal pvalue distribution and qvalue calculation
... Without any further information about your data (e.g. maybe discrete tests), the results you obtain from qvalue appear plausible to me. What you are discovering here is that in many cases, from a statistical perspective, the problem of detection is much easier than the problem of localization. In ot ...
written 7 days ago by Nikos Ignatiadis130
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Answer: A: Libgomp error in IHW
... Hello! Indeed this appears to be related to the parallelization in Lpsymphony. Can you give some more context about your problem? How many p-values do you have and what are the covariates? Furthermore, as a basic sanity check, can you run the IHW examples (either in the documentation or the vignette ...
written 3 months ago by Nikos Ignatiadis130
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Answer: A: IHWpaper: choice of `nbins=4` in `proteomics_example_analysis.R`
... Hi Paul, it's a good question. As is so often the case, this is just a bias/variance/computation time tradeoff. Here by bias-variance I refer to the estimation of the weight function from the rest of the folds and applying it to the held-out fold. In general, in the default choices in the IHW packa ...
written 12 months ago by Nikos Ignatiadis130
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Comment: C: IHW Package for R 3.2.5
... Mike's suggestion is the most elegant one and I'd recommend you go that route. If you really can't move to another version, you could probably manually download IHW and its dependencies and manually change the R version requirements in the `DESCRIPTION` file. It should probably work (although not te ...
written 14 months ago by Nikos Ignatiadis130
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Answer: A: IHW and correlated covariates
... Hi Mike, I am afraid this will largely be a non-answer, since right now the support for multivariate covariates is minimal: You have to manually bin covariates into higher dimensional rectangles, with the obvious repercussions in terms of the curse of dimensionality. One thing you could do is just ...
written 18 months ago by Nikos Ignatiadis130
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Answer: A: genefilter filtered out 60% of the original genes?
... A key diagnostic to figure out whether the cutoff of 60% is reasonable would be to check how many rejections you get after applying this procedure (and possibly also compare to the baseline without any filtering). If the number of rejections is very low, then I would worry. If the number of rejectio ...
written 2.1 years ago by Nikos Ignatiadis130
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Answer: A: Possible to incorporate the sign or direction of an effect in the IHW covariate?
... Hi, this is the first IHW question on the support forums and a good one! Actually there are two distinct parts to your question: 1. Can the direction of the effect be used as a covariate? It depends on the application, but in many cases you can. In particular, it should be valid (i.e. conditional ...
written 2.2 years ago by Nikos Ignatiadis130

Latest awards to Nikos Ignatiadis

Scholar 12 months ago, created an answer that has been accepted. For A: genefilter filtered out 60% of the original genes?
Teacher 12 months ago, created an answer with at least 3 up-votes. For A: Possible to incorporate the sign or direction of an effect in the IHW covariate?
Scholar 2.2 years ago, created an answer that has been accepted. For A: Possible to incorporate the sign or direction of an effect in the IHW covariate?
Teacher 2.2 years ago, created an answer with at least 3 up-votes. For A: Possible to incorporate the sign or direction of an effect in the IHW covariate?
Scholar 2.2 years ago, created an answer that has been accepted. For A: Possible to incorporate the sign or direction of an effect in the IHW covariate?

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