Question: weights must be finite positive value

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nonCodingGene •

**10**wrote:I'm using `edgeR and an error for which I have not found a solution just appeared.`

design <- model.matrix(~Cell.type, data = colData(summ.exp_norm)) dge$weights <- zinb.weights dge <- estimateDisp(dge, design) Error in .compressWeights(y, weights) : weights must be finite positive values

As you can se no weight is out the rang 0-1 or infinite.

> sum(is.infinite(dge$weights)) [1] 0

Where can the error be?

Thanks

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modified 28 days ago
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Aaron Lun •

**20k**• written 28 days ago by nonCodingGene •**10**
Why do you think

`is.infinite`

will tell you if any values are less than zero? Or for that matter, within the range 0-1?47kSorry, I forgot to show that also tested for

`max(`

`dge$weights)`

and`min(`

`dge$weights), and values where 1 and 0.`

10Well, the test is

So really it's saying you have either negative or NA values. This comes after running

`makeCompressedMatrix`

, so you might see if there are any NA values after that step with your weights matrix.47k10